Kun-Hyung Roh
Bronx High School of Science
Bronx, NY
Novel Drug Discovery Methodology Using Machine Learning for Gene Expression-Based Virtual Screening Predicts Novel Compounds To Reverse Alzheimer鈥檚 Disease With Applications to Cancer and Longevity by Inhibiting CtBP2 Expression
Kyle Roh developed A.I. software that he believes could help predict potential future drugs for Alzheimer鈥檚 disease and other conditions by determining their genetic targets rather than focusing on the resulting protein. He believes his work could make new drug development cheaper and faster.
Kun-Hyung Roh, 18, of New York, created A.I. software that may ease potential drug discovery by identifying compounds that inhibit gene expression of proteins rather than focusing on the protein structure for his Regeneron Science Talent Search neuroscience project. Kun-Hyung focused on Alzheimer鈥檚 disease (AD) and current drug options called phenothiazines, which appear to reduce AD-related brain inflammation.
To try to determine how phenothiazines work in the brain, Kun-Hyung developed a machine-learning method that determined the drugs are targeting the expression of a specific gene鈥檚 protein whose levels are higher in the brains of AD patients, yet whose structure makes it difficult for the drugs鈥� small molecules to attach well, reducing their effectiveness. Using his A.I. model, he identified other potential substances that reduce the gene鈥檚 expression and lower protein levels. He believes his model may save valuable time in drug discovery for AD.
Kun-Hyung founded the machine learning club at the Bronx High School of Science, which established a partnership with a nonprofit to teach free computer science classes to middle schoolers. The son of Yang Soo Kim and Taeho Roh, Kun-Hyung wants to discover new affordable disease treatments.
Beyond the Project
Kyle loves cooking pasta and finding new recipes and he is obsessed with perfecting his sauces. He refers to his block of Parmesan cheese as his 鈥渟aucerer鈥檚 stone.鈥�
FUN FACTS: Kyle is a believer in the Korean concept 鈥渏amanchu,鈥� which refers to bringing people together in a natural way. He has 鈥渕atchmade鈥� project teams, startup partners, and 鈥渙f course, romantic couples.鈥�
